Furnari
Laboratory
Advancing Brain Cancer Biology and Therapy Through Innovation, Collaboration, and Discovery
Key Areas of Research
Our work centers on understanding the biology of malignant brain tumors, by exploring how genetics, cell signaling, and the tumor microenvironment shape disease behavior and treatment response in adults and pediatric patients.
Tumor Heterogeneity
How expression of amplified extracellular domain mutants of the epidermal growth factor gene (EGFR) enhance tumor aggressiveness and promote therapeutic resistance
Next Generation Brain Tumor Models
Engineering of next generation tumor models that accurately recapitulate the spectrum of subtype driver mutations and the evolution of adult and pediatric brain tumor
Tumor Vulnerabilities and Genetic Dependencies
Identifying therapeutically actionable targets
Brief Insight into the
Furnari Lab
The Furnari Lab is dedicated to understanding the biology of malignant brain tumors, with a particular focus on glioblastoma, the most aggressive primary brain cancer. Our research explores the genetic, molecular, and microenvironmental mechanisms that allow these tumors to grow, evolve, and resist therapy. By studying tumor signaling pathways, cellular heterogeneity, and interactions within the tumor microenvironment, we aim to uncover the key drivers of disease behavior at both the molecular and systems level.
A central mission of the lab is to translate scientific discovery into meaningful clinical impact. Using patient-derived models and collaborative research approaches, we work to identify new therapeutic vulnerabilities and treatment strategies that may improve outcomes for people affected by brain cancer. Our publications reflect an ongoing commitment to advancing the scientific understanding of glioblastoma while training the next generation of cancer researchers and physician-scientists.
Some of Our Statistics
Grants & Funding
A Glimpse of Our Research on Brain Cancer
We study the biological mechanisms that drive aggressive brain cancers such as glioblastoma. By exploring how genetics, cell signaling, and the tumor microenvironment shape tumor growth and therapy resistance, we aim to identify new therapeutic vulnerabilities and advance the future of brain cancer treatment.