The primary focus of our research is to study fundamental pathways that drive initiation and progression of glioblastoma, as well as the malignant phenotypes of this aggressive brain cancer, ranging from tumor biology, biochemistry, cell biology, signal transduction and bioinformatic analyses, to orthotopic glioma models and preclinical investigations. Our program has the following main objectives with the overarching goal of molecularly understanding and eradicating glioblastoma and other types of brain cancer: